AustralieFrV1, Main, Exploration, bibRecord, 004D63

Outcomes of Antiretroviral Therapy in Children in Asia and Africa: A Comparative Analysis of the leDEA Pediatric Multiregional Collaboration

Identifieur interne : 004D63 ( Main/Exploration ); précédent : 004D62; suivant : 004D64

Outcomes of Antiretroviral Therapy in Children in Asia and Africa: A Comparative Analysis of the leDEA Pediatric Multiregional Collaboration

Auteurs : Valeriane Leroy [France] ; Karen Malateste [France] ; Helena Rabie [Afrique du Sud] ; Pagakrong Lumbiganon [Thaïlande] ; Samuel Ayaya [Kenya] ; Fatoumata Dicko [Mali] ; Mary-Ann Davies [Afrique du Sud] ; Azar Kariminia [Australie] ; Kara Wools-Kaloustian [États-Unis] ; Edmond Aka [France] ; Samuel Phiri [Malawi] ; Linda Aurpibul [Thaïlande] ; Constantin Yiannoutsos [Sénégal] ; Haby Signate-Sy [États-Unis] ; Lynne Mofenson [France, Australie] ; François Dabis [France]

Source :

Journal of acquired immune deficiency syndromes : (1999) [ 1525-4135 ] ; 2013.

RBID : Pascal:13-0114986

Descripteurs français

Pascal (Inist)
- Pronostic, Antiviral, Antirétroviral, Traitement, Enfant, Asie, Afrique, Etude cohorte, SIDA.
Wicri :
- topic : Enfant.

English descriptors

KwdEn :
- AIDS, Africa, Antiretroviral agent, Antiviral, Asia, Child, Cohort study, Prognosis, Treatment.

Abstract

Background: We investigated 18-month incidence and determinants of death and loss to follow-up of children after antiretroviral therapy (ART) initiation in a multiregional collaboration in lower-income countries. Methods: HIV-infected children (positive polymerase chain reaction <18 months or positive serology ≥18 months) from International Epidemiologic Databases to Evaluate AIDS cohorts, < 16 years, initiating ART were eligible. A competing risk regression model was used to analyze the independent risk of 2 failure types: death and loss to follow-up (>6 months). Findings: Data on 13,611 children, from Asia (N = 1454), East Africa (N = 3114), Southern Africa (N = 6212), and West Africa (N = 2881) contributed 20,417 person-years of follow-up. At 18 months, the adjusted risk of death was 4.3% in East Africa, 5.4% in Asia, 5.7% in Southern Africa, and 7.4% in West Africa (P = 0.01). Age < 24 months, World Health Organization stage 4, CD4 < 10%, attending a private sector clinic, larger cohort size, and living in West Africa were independently associated with poorer survival. The adjusted risk of loss to follow-up was 4.1% in Asia, 9.0% in Southern Africa, 14.0% in East Africa, and 21.8% in West Africa (P < 0.01). Age < 12 months, nonnucleoside reverse transcriptase inhibitor I-based ART regimen, World Health Organization stage 4 at ART start, ART initiation after 2005, attending a public sector or a nonurban clinic, having to pay for laboratory tests or antiretroviral drugs, larger cohort size, and living in East Africa or West Africa were significantly associated with higher loss to follow-up. Conclusions: Findings differed substantially across regions but raise overall concerns about delayed ART start, low access to free HIV services for children, and increased workload on program retention in lower-income countries. Universal free access to ART services and innovative approaches are urgently needed to improve pediatric outcomes at the program level.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556242

Affiliations:

Afrique du Sud, Australie, France, Kenya, Malawi, Mali, Sénégal, Thaïlande, États-Unis
Aquitaine, Nouvelle-Aquitaine, Nouvelle-Galles du Sud
Bordeaux, Sydney

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Outcomes of Antiretroviral Therapy in Children in Asia and Africa: A Comparative Analysis of the leDEA Pediatric Multiregional Collaboration</title>
<author><name sortKey="Leroy, Valeriane" sort="Leroy, Valeriane" uniqKey="Leroy V" first="Valeriane" last="Leroy">Valeriane Leroy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
<wicri:noRegion>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut de Santé Publique, Epidemiologie et Développement (ISPED), Bordeaux Segalen University</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malateste, Karen" sort="Malateste, Karen" uniqKey="Malateste K" first="Karen" last="Malateste">Karen Malateste</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
<wicri:noRegion>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut de Santé Publique, Epidemiologie et Développement (ISPED), Bordeaux Segalen University</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabie, Helena" sort="Rabie, Helena" uniqKey="Rabie H" first="Helena" last="Rabie">Helena Rabie</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Tygerberg Academic Hospital, Stellenbosch University</s1>
<s2>Cape Town</s2>
<s3>ZAF</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Afrique du Sud</country>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lumbiganon, Pagakrong" sort="Lumbiganon, Pagakrong" uniqKey="Lumbiganon P" first="Pagakrong" last="Lumbiganon">Pagakrong Lumbiganon</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Khon Kaen University</s1>
<s2>Khon Kaen</s2>
<s3>THA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Thaïlande</country>
<wicri:noRegion>Khon Kaen University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ayaya, Samuel" sort="Ayaya, Samuel" uniqKey="Ayaya S" first="Samuel" last="Ayaya">Samuel Ayaya</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Moi Teaching and Referral Hospital</s1>
<s2>Eldoret</s2>
<s3>KEN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Kenya</country>
<wicri:noRegion>Moi Teaching and Referral Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dicko, Fatoumata" sort="Dicko, Fatoumata" uniqKey="Dicko F" first="Fatoumata" last="Dicko">Fatoumata Dicko</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Hop Gabriel Toure</s1>
<s2>Bamako</s2>
<s3>MLI</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Mali</country>
<wicri:noRegion>Hop Gabriel Toure</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davies, Mary Ann" sort="Davies, Mary Ann" uniqKey="Davies M" first="Mary-Ann" last="Davies">Mary-Ann Davies</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Center for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town</s1>
<s3>ZAF</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Afrique du Sud</country>
<wicri:noRegion>Center for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kariminia, Azar" sort="Kariminia, Azar" uniqKey="Kariminia A" first="Azar" last="Kariminia">Azar Kariminia</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>National Center in HIV Epidemiology and Clinical Research</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wools Kaloustian, Kara" sort="Wools Kaloustian, Kara" uniqKey="Wools Kaloustian K" first="Kara" last="Wools-Kaloustian">Kara Wools-Kaloustian</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>School of Medicine, Indiana University</s1>
<s2>Indianapolis, IN</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Indianapolis, IN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aka, Edmond" sort="Aka, Edmond" uniqKey="Aka E" first="Edmond" last="Aka">Edmond Aka</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Center de Prise en Charge, de Recherche et de Formation, CePReF</s1>
<s2>Abidjan, Côte d'Ivoire</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Côte d'Ivoire</wicri:noRegion>
<wicri:noRegion>CePReF</wicri:noRegion>
<wicri:noRegion>Abidjan, Côte d'Ivoire</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Phiri, Samuel" sort="Phiri, Samuel" uniqKey="Phiri S" first="Samuel" last="Phiri">Samuel Phiri</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Lighthouse Clinic</s1>
<s2>Lilongwe</s2>
<s3>MWI</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Malawi</country>
<wicri:noRegion>Lighthouse Clinic</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aurpibul, Linda" sort="Aurpibul, Linda" uniqKey="Aurpibul L" first="Linda" last="Aurpibul">Linda Aurpibul</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Chiang Mai University</s1>
<s3>THA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Thaïlande</country>
<wicri:noRegion>Chiang Mai University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yiannoutsos, Constantin" sort="Yiannoutsos, Constantin" uniqKey="Yiannoutsos C" first="Constantin" last="Yiannoutsos">Constantin Yiannoutsos</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Hopital Albert Royer</s1>
<s2>Dakar</s2>
<s3>SEN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Sénégal</country>
<wicri:noRegion>Hopital Albert Royer</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Signate Sy, Haby" sort="Signate Sy, Haby" uniqKey="Signate Sy H" first="Haby" last="Signate-Sy">Haby Signate-Sy</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Rockville, MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mofenson, Lynne" sort="Mofenson, Lynne" uniqKey="Mofenson L" first="Lynne" last="Mofenson">Lynne Mofenson</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
<wicri:noRegion>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>National Center in HIV Epidemiology and Clinical Research</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="François" last="Dabis">François Dabis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
<wicri:noRegion>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut de Santé Publique, Epidemiologie et Développement (ISPED), Bordeaux Segalen University</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0114986</idno>
<date when="2013">2013</date>
<idno type="stanalyst">PASCAL 13-0114986 INIST</idno>
<idno type="RBID">Pascal:13-0114986</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000B70</idno>
<idno type="wicri:Area/PascalFrancis/Curation">005295</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000744</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000744</idno>
<idno type="wicri:doubleKey">1525-4135:2013:Leroy V:outcomes:of:antiretroviral</idno>
<idno type="wicri:Area/Main/Merge">004F18</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556242</idno>
<idno type="RBID">PMC:3556242</idno>
<idno type="wicri:Area/Pmc/Corpus">001D65</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D65</idno>
<idno type="wicri:Area/Pmc/Curation">001C21</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C21</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001967</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001967</idno>
<idno type="wicri:Area/Ncbi/Merge">001046</idno>
<idno type="wicri:Area/Ncbi/Curation">001046</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001046</idno>
<idno type="wicri:doubleKey">1525-4135:2013:Leroy V:outcomes:of:antiretroviral</idno>
<idno type="wicri:Area/Main/Merge">004660</idno>
<idno type="wicri:Area/Main/Curation">004D63</idno>
<idno type="wicri:Area/Main/Exploration">004D63</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Outcomes of Antiretroviral Therapy in Children in Asia and Africa: A Comparative Analysis of the leDEA Pediatric Multiregional Collaboration</title>
<author><name sortKey="Leroy, Valeriane" sort="Leroy, Valeriane" uniqKey="Leroy V" first="Valeriane" last="Leroy">Valeriane Leroy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
<wicri:noRegion>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut de Santé Publique, Epidemiologie et Développement (ISPED), Bordeaux Segalen University</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malateste, Karen" sort="Malateste, Karen" uniqKey="Malateste K" first="Karen" last="Malateste">Karen Malateste</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
<wicri:noRegion>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut de Santé Publique, Epidemiologie et Développement (ISPED), Bordeaux Segalen University</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabie, Helena" sort="Rabie, Helena" uniqKey="Rabie H" first="Helena" last="Rabie">Helena Rabie</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Tygerberg Academic Hospital, Stellenbosch University</s1>
<s2>Cape Town</s2>
<s3>ZAF</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Afrique du Sud</country>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lumbiganon, Pagakrong" sort="Lumbiganon, Pagakrong" uniqKey="Lumbiganon P" first="Pagakrong" last="Lumbiganon">Pagakrong Lumbiganon</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Khon Kaen University</s1>
<s2>Khon Kaen</s2>
<s3>THA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Thaïlande</country>
<wicri:noRegion>Khon Kaen University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ayaya, Samuel" sort="Ayaya, Samuel" uniqKey="Ayaya S" first="Samuel" last="Ayaya">Samuel Ayaya</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Moi Teaching and Referral Hospital</s1>
<s2>Eldoret</s2>
<s3>KEN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Kenya</country>
<wicri:noRegion>Moi Teaching and Referral Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dicko, Fatoumata" sort="Dicko, Fatoumata" uniqKey="Dicko F" first="Fatoumata" last="Dicko">Fatoumata Dicko</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Hop Gabriel Toure</s1>
<s2>Bamako</s2>
<s3>MLI</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Mali</country>
<wicri:noRegion>Hop Gabriel Toure</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davies, Mary Ann" sort="Davies, Mary Ann" uniqKey="Davies M" first="Mary-Ann" last="Davies">Mary-Ann Davies</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Center for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town</s1>
<s3>ZAF</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Afrique du Sud</country>
<wicri:noRegion>Center for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kariminia, Azar" sort="Kariminia, Azar" uniqKey="Kariminia A" first="Azar" last="Kariminia">Azar Kariminia</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>National Center in HIV Epidemiology and Clinical Research</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wools Kaloustian, Kara" sort="Wools Kaloustian, Kara" uniqKey="Wools Kaloustian K" first="Kara" last="Wools-Kaloustian">Kara Wools-Kaloustian</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>School of Medicine, Indiana University</s1>
<s2>Indianapolis, IN</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Indianapolis, IN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aka, Edmond" sort="Aka, Edmond" uniqKey="Aka E" first="Edmond" last="Aka">Edmond Aka</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Center de Prise en Charge, de Recherche et de Formation, CePReF</s1>
<s2>Abidjan, Côte d'Ivoire</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Côte d'Ivoire</wicri:noRegion>
<wicri:noRegion>CePReF</wicri:noRegion>
<wicri:noRegion>Abidjan, Côte d'Ivoire</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Phiri, Samuel" sort="Phiri, Samuel" uniqKey="Phiri S" first="Samuel" last="Phiri">Samuel Phiri</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Lighthouse Clinic</s1>
<s2>Lilongwe</s2>
<s3>MWI</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Malawi</country>
<wicri:noRegion>Lighthouse Clinic</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aurpibul, Linda" sort="Aurpibul, Linda" uniqKey="Aurpibul L" first="Linda" last="Aurpibul">Linda Aurpibul</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Chiang Mai University</s1>
<s3>THA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Thaïlande</country>
<wicri:noRegion>Chiang Mai University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yiannoutsos, Constantin" sort="Yiannoutsos, Constantin" uniqKey="Yiannoutsos C" first="Constantin" last="Yiannoutsos">Constantin Yiannoutsos</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Hopital Albert Royer</s1>
<s2>Dakar</s2>
<s3>SEN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Sénégal</country>
<wicri:noRegion>Hopital Albert Royer</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Signate Sy, Haby" sort="Signate Sy, Haby" uniqKey="Signate Sy H" first="Haby" last="Signate-Sy">Haby Signate-Sy</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Rockville, MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mofenson, Lynne" sort="Mofenson, Lynne" uniqKey="Mofenson L" first="Lynne" last="Mofenson">Lynne Mofenson</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
<wicri:noRegion>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>National Center in HIV Epidemiology and Clinical Research</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="François" last="Dabis">François Dabis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
<wicri:noRegion>Inserm, U897, Epidemiologie-Biostatistiques-Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut de Santé Publique, Epidemiologie et Développement (ISPED), Bordeaux Segalen University</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
<title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title>
<idno type="ISSN">1525-4135</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
<title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title>
<idno type="ISSN">1525-4135</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Africa</term>
<term>Antiretroviral agent</term>
<term>Antiviral</term>
<term>Asia</term>
<term>Child</term>
<term>Cohort study</term>
<term>Prognosis</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pronostic</term>
<term>Antiviral</term>
<term>Antirétroviral</term>
<term>Traitement</term>
<term>Enfant</term>
<term>Asie</term>
<term>Afrique</term>
<term>Etude cohorte</term>
<term>SIDA</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: We investigated 18-month incidence and determinants of death and loss to follow-up of children after antiretroviral therapy (ART) initiation in a multiregional collaboration in lower-income countries. Methods: HIV-infected children (positive polymerase chain reaction <18 months or positive serology ≥18 months) from International Epidemiologic Databases to Evaluate AIDS cohorts, < 16 years, initiating ART were eligible. A competing risk regression model was used to analyze the independent risk of 2 failure types: death and loss to follow-up (>6 months). Findings: Data on 13,611 children, from Asia (N = 1454), East Africa (N = 3114), Southern Africa (N = 6212), and West Africa (N = 2881) contributed 20,417 person-years of follow-up. At 18 months, the adjusted risk of death was 4.3% in East Africa, 5.4% in Asia, 5.7% in Southern Africa, and 7.4% in West Africa (P = 0.01). Age < 24 months, World Health Organization stage 4, CD4 < 10%, attending a private sector clinic, larger cohort size, and living in West Africa were independently associated with poorer survival. The adjusted risk of loss to follow-up was 4.1% in Asia, 9.0% in Southern Africa, 14.0% in East Africa, and 21.8% in West Africa (P < 0.01). Age < 12 months, nonnucleoside reverse transcriptase inhibitor I-based ART regimen, World Health Organization stage 4 at ART start, ART initiation after 2005, attending a public sector or a nonurban clinic, having to pay for laboratory tests or antiretroviral drugs, larger cohort size, and living in East Africa or West Africa were significantly associated with higher loss to follow-up. Conclusions: Findings differed substantially across regions but raise overall concerns about delayed ART start, low access to free HIV services for children, and increased workload on program retention in lower-income countries. Universal free access to ART services and innovative approaches are urgently needed to improve pediatric outcomes at the program level.</div>
</front>
</TEI>
<affiliations><list><country><li>Afrique du Sud</li>
<li>Australie</li>
<li>France</li>
<li>Kenya</li>
<li>Malawi</li>
<li>Mali</li>
<li>Sénégal</li>
<li>Thaïlande</li>
<li>États-Unis</li>
</country>
<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
<li>Nouvelle-Galles du Sud</li>
</region>
<settlement><li>Bordeaux</li>
<li>Sydney</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Leroy, Valeriane" sort="Leroy, Valeriane" uniqKey="Leroy V" first="Valeriane" last="Leroy">Valeriane Leroy</name>
</noRegion>
<name sortKey="Aka, Edmond" sort="Aka, Edmond" uniqKey="Aka E" first="Edmond" last="Aka">Edmond Aka</name>
<name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="François" last="Dabis">François Dabis</name>
<name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="François" last="Dabis">François Dabis</name>
<name sortKey="Leroy, Valeriane" sort="Leroy, Valeriane" uniqKey="Leroy V" first="Valeriane" last="Leroy">Valeriane Leroy</name>
<name sortKey="Malateste, Karen" sort="Malateste, Karen" uniqKey="Malateste K" first="Karen" last="Malateste">Karen Malateste</name>
<name sortKey="Malateste, Karen" sort="Malateste, Karen" uniqKey="Malateste K" first="Karen" last="Malateste">Karen Malateste</name>
<name sortKey="Mofenson, Lynne" sort="Mofenson, Lynne" uniqKey="Mofenson L" first="Lynne" last="Mofenson">Lynne Mofenson</name>
</country>
<country name="Afrique du Sud"><noRegion><name sortKey="Rabie, Helena" sort="Rabie, Helena" uniqKey="Rabie H" first="Helena" last="Rabie">Helena Rabie</name>
</noRegion>
<name sortKey="Davies, Mary Ann" sort="Davies, Mary Ann" uniqKey="Davies M" first="Mary-Ann" last="Davies">Mary-Ann Davies</name>
</country>
<country name="Thaïlande"><noRegion><name sortKey="Lumbiganon, Pagakrong" sort="Lumbiganon, Pagakrong" uniqKey="Lumbiganon P" first="Pagakrong" last="Lumbiganon">Pagakrong Lumbiganon</name>
</noRegion>
<name sortKey="Aurpibul, Linda" sort="Aurpibul, Linda" uniqKey="Aurpibul L" first="Linda" last="Aurpibul">Linda Aurpibul</name>
</country>
<country name="Kenya"><noRegion><name sortKey="Ayaya, Samuel" sort="Ayaya, Samuel" uniqKey="Ayaya S" first="Samuel" last="Ayaya">Samuel Ayaya</name>
</noRegion>
</country>
<country name="Mali"><noRegion><name sortKey="Dicko, Fatoumata" sort="Dicko, Fatoumata" uniqKey="Dicko F" first="Fatoumata" last="Dicko">Fatoumata Dicko</name>
</noRegion>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Kariminia, Azar" sort="Kariminia, Azar" uniqKey="Kariminia A" first="Azar" last="Kariminia">Azar Kariminia</name>
</region>
<name sortKey="Mofenson, Lynne" sort="Mofenson, Lynne" uniqKey="Mofenson L" first="Lynne" last="Mofenson">Lynne Mofenson</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Wools Kaloustian, Kara" sort="Wools Kaloustian, Kara" uniqKey="Wools Kaloustian K" first="Kara" last="Wools-Kaloustian">Kara Wools-Kaloustian</name>
</noRegion>
<name sortKey="Signate Sy, Haby" sort="Signate Sy, Haby" uniqKey="Signate Sy H" first="Haby" last="Signate-Sy">Haby Signate-Sy</name>
</country>
<country name="Malawi"><noRegion><name sortKey="Phiri, Samuel" sort="Phiri, Samuel" uniqKey="Phiri S" first="Samuel" last="Phiri">Samuel Phiri</name>
</noRegion>
</country>
<country name="Sénégal"><noRegion><name sortKey="Yiannoutsos, Constantin" sort="Yiannoutsos, Constantin" uniqKey="Yiannoutsos C" first="Constantin" last="Yiannoutsos">Constantin Yiannoutsos</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004D63 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004D63 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:13-0114986
   |texte=   Outcomes of Antiretroviral Therapy in Children in Asia and Africa: A Comparative Analysis of the leDEA Pediatric Multiregional Collaboration
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Outcomes of Antiretroviral Therapy in Children in Asia and Africa: A Comparative Analysis of the leDEA Pediatric Multiregional Collaboration

Outcomes of Antiretroviral Therapy in Children in Asia and Africa: A Comparative Analysis of the leDEA Pediatric Multiregional Collaboration

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.